I ordered too many of the large size of P5P50 by Pure Encapsulations. P5P50 is the active form of B6. B6 is needed for several inflammatory pathways to reduce inflammation. It is necessary to support several detoxification pathways. B6 is also needed to break down histamine (it helps with allergies) and is also a prerequisite for several neurotransmitters (helps with depression and anxiety). Please note that this is only for the larger 180-count size.