15-30% of the population have a genetic defect that keeps them from fully converting folate to its final usable form. We have trouble producing the methylenetetrahydrofolate reductase enzyme needed for the final conversion. Folate is needed for the production of several neurotransmitters, is needed to assist several detoxification pathways, and is also critical in reducing inflammation. 5-MTHF is the final usable form of folate that our bodies can put directly to use. It can make a big difference for those of us with genetic deficiency. Read more here. For the month of February, all 5-MTHF products will be 20% off.